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Following your initial visit with Dr. Blyweiss, in addition to a review of your bloodwork, previous diagnostic tests, a physical exam and history review, you may be asked to have additional diagnostic tests performed. These tests are unique in that they are not done in conventional medical offices.
Plasma asymmetric dimethylarginine (ADMA) is a primary endogenous inhibitor of nitric oxide synthase that inhibits nitric oxide production. Elevated levels are implicated in cardiovascular disease and are a cause of hypertension, hyperhomocysteinemia, diabetes mellitus types 1 & 2, and pre-eclampsia. ADMA becomes elevated due to loss of activity for the ADMA-degarding enzyme DDAH when antioxidant protection is lacking.
Blood Amino Acids
Amino acid analyses aid in the assessment of: dietary protein adequacy and balance, gastrointestinal dysfunctions, forms of protein intolerance, nutritional deficiencies (vitamins, minerals), renal and hepatic dysfunction, psychiatric abnormalities, susceptibility to inflammatory response and oxidative stress, reduced detoxification capacity, susceptibility to occlusive arterial disease, and many inherent disorders of amino acid metabolism. Many free amino acids such as histidine, lysine, threonine and serine in plasma provide toxic element ligands for transport and renal excretion. Amino acid hepatic flux stimulates carcinogenic toxicant conjugation reactions. Amino acid analysis also shows phase II biotransformation substrates (glycine and sulfur amino acids) and status of glutathione precursor amino acids methionine and glycine. Fasting plasma and whole blood (bloodspot) levels provide a reliable assessment of dietary adequacy. Plasma hydroxylysine and hydroxyproline become elevated due to increased rates of bone reabsorption.
Blood Antioxidant Capacity
T-lymphocytes are cultured under optimal growth conditions and, following mitogenic stimulation, are exposed to increasing concentrations of free radicals to measure the cell’s ability to resist oxidative stress. Specific antioxidants (i.e., selenium, tocopherols, glutathione, Coq10, etc.) are available to identify specific intracellular functional deficiencies that may limit antioxidant capacity within a highly interactive system of antioxidants.
Blood Candida Antibody/Antigen
Serum IgM, IgG, IgA antibodies for Candida albicans are used to indirectly assess current, past, and mucosal exposure to this yeast, respectively. Serum Candida albicans (antigen) is measured to identify its presence in circulation. Candida is associated with both acute and chronic conditions.
Blood Celiac Profile
Total immunoglobulins A, tissue transglutaminase IgA, and anti-gliadin IgA are measured. An elevated tissue transglutaminase IgA is highly sensitive and specific for gastrointestinal villous atrophy associated with Celiac. An elevated anti-gliadin IgA indicates specific gluten-activated immune response.
Serum assays provide an accurate and time-tested assessment of estrogen, progesterone, testosterone, and DHEA at a point in time. Sex hormone binding globulin (SHBG) is also measured in serum to provide an estimate of free testosterone and estradiol, which are primarily bound by this protein. These hormones are assessed to evaluate ovarian and adrenal dysfunction, and to determine need and dose of related hormone replacement therapy.
Blood Fatty Acids (plasma, RBC, blood spot)
Fatty acid (FA) profiles show quantitative results for individual fatty acids, including polyunsaturated omega-3 (including ALA, EPA, DHA), omega-6 (including GLA, DGLA, AA), omega-9 (including oleic, nervonic), saturates (including capric, palmitic, stearic, hexcosanoic), and trans-fatty acids. Fatty acid ratios such as LA/DGLA and AA/EPA are calculated to help identify imbalances. Essential FA deficiencies and metabolic effects manifest as imbalances within and between families of fatty acids.
